second uh but the the reason why we're |
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|
|
i think the first psychedelics company |
4.8 |
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|
all those details and we have the two |
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|
um i first want to i first want to |
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|
|
jack so first i'd like to say jack thank |
4.4 |
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|
|
uh three years ago |
4.079 |
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|
|
which as we know is the number one |
4.96 |
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|
|
so about three years ago |
4.479 |
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DATE
about three years ago
|
|
provide one-on-one in-home aba services |
5.359 |
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|
|
two of you connect uh nova mentis dr |
6.0 |
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|
|
special needs for almost 12 years now |
5.04 |
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|
|
specializing in autism for the last five |
3.44 |
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|
|
really an expert you're actually one of |
3.679 |
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|
|
if you just focus on one |
4.48 |
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|
|
our phase two-way study |
4.959 |
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|
|
two-way study with health canada so it's |
5.2 |
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|
|
first |
3.681 |
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|
|
four |
4.479 |
Jump to 435.12 |
|
|
fruit kingdom in the world 40 000 |
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|
|
need to research so i chose about 30 |
5.12 |
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|
|
ten |
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|
|
which is one of the largest food science |
4.08 |
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|
|
and as that child develops to age seven |
6.48 |
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|
|
eight nine its serotonin level starts |
6.24 |
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|
|
age one age two |
4.479 |
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|
|
52 genetic mrna i didn't create them i |
6.159 |
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|
|
and we're going to measure the 52 mrna |
6.0 |
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|
|
and we're going to do that for 30 days |
4.241 |
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|
|
day zero |
4.4 |
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|
|
two weeks after treatment |
5.039 |
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|
|
four weeks after treatment and two weeks |
4.96 |
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|
|
for 30 days |
5.2 |
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|
|
and and you call 9-1-1 |
6.32 |
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|
|
the mrna 52 genes serotonin levels |
8.719 |
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|
|
you know so autumn is not one thing it's |
5.039 |
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|
|
child is affected across let's say three |
4.0 |
Jump to 942.48 |
|
|
of the four domains they will meet |
3.92 |
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|
|
like what do 52 genes look like we |
5.201 |
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|
|
know 20 years ago you know |
3.92 |
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|
|
everywhere what's what is so first of |
4.32 |
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|
|
you know obviously we're 15 minutes into |
3.36 |
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|
|
one |
3.52 |
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|
|
one in 40 or 150 kiddos are being |
5.52 |
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|
|
diagnosed whereas again going back 30 40 |
4.48 |
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|
|
get here about six to eight weeks |
4.56 |
Jump to 1231.44 |
DATE
about six to eight weeks
|
|
water we could take a break for a second |
5.161 |
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|
|
of one to six or one to seven that's |
4.08 |
Jump to 1331.44 |
|
|
it goes from you know six months eight |
4.0 |
Jump to 1383.6 |
|
|
months two years three years |
4.239 |
Jump to 1385.44 |
DATE
months two years three years
|
|
um you know they're four or five years |
3.201 |
Jump to 1389.679 |
|
|
only five percent remember we talked |
4.24 |
Jump to 1495.12 |
PERCENT
only five percent
|
|
only five percent of serotonin is |
4.721 |
Jump to 1502.159 |
PERCENT
only five percent
|
|
95 percent in the bowel |
6.399 |
Jump to 1506.88 |
|
|
try to approach why one to two percent |
6.321 |
Jump to 1557.679 |
PERCENT
one to two percent
|
|
for a 70 percent water |
5.36 |
Jump to 1686.24 |
|
|
a 70 kilogram male or female |
7.6 |
Jump to 1691.6 |
|
|
is 30 trillion human cells |
5.759 |
Jump to 1695.52 |
|
|
show them close a hundred trillion |
4.961 |
Jump to 1701.279 |
|
|
with three times more bacteria so our |
5.36 |
Jump to 1706.24 |
|
|
think about it we only have 30 million |
5.439 |
Jump to 1713.84 |
|
|
trillion mammalian cells and 100 |
5.2 |
Jump to 1716.88 |
|
|
trillion bacteria in our skin |
5.841 |
Jump to 1719.279 |
|
|
if one was the answer |
5.681 |
Jump to 1921.279 |
|
|
is 70 percent water |
4.88 |
Jump to 1949.519 |
|
|
five-year-old child |
2.72 |
Jump to 1981.36 |
|
|
so again for the last 30 40 years the |
5.2 |
Jump to 2004.88 |
DATE
the last 30 40 years
|
|
only evidence-based intervention with 30 |
4.72 |
Jump to 2100.96 |
|
|
or 40 years of research behind it |
3.441 |
Jump to 2103.119 |
|
|
of one two or three and that that |
5.119 |
Jump to 2114.24 |
CARDINAL
one two or three
|
|
illustrates your severity so a level one |
5.68 |
Jump to 2116.32 |
|
|
level three that's when you have an |
5.04 |
Jump to 2130.0 |
|
|
which can look like 30 or 40 hours a |
6.0 |
Jump to 2152.88 |
|
|
know for 26 years of my life i haven't |
4.64 |
Jump to 2221.28 |
|
|
they don't have to go 20 years of of |
6.96 |
Jump to 2253.68 |
|
|
kiddo that's two or three we might be |
4.8 |
Jump to 2265.76 |
|
|
we're doing this phase two-way study in |
4.72 |
Jump to 2375.92 |
|
|
five attempts |
6.08 |
Jump to 2400.88 |
|
|
general autism and two attempts with |
4.799 |
Jump to 2403.52 |
|
|
from the phase two-way study |
3.76 |
Jump to 2418.48 |
|
|
or anxiety by 10 |
5.68 |
Jump to 2424.8 |
|
|
i have a five-hour window in a day to |
6.081 |
Jump to 2491.119 |
|
|
to self stimulate for that entire five |
5.28 |
Jump to 2500.079 |
|
|
five percent so in that five hour window |
4.48 |
Jump to 2511.119 |
|
|
collectively maybe 10 to 20 minutes of |
5.921 |
Jump to 2515.599 |
|
|
that reduces those symptoms even by 10 |
5.2 |
Jump to 2526.96 |
|
|
15 percent as marvin said we now take |
4.159 |
Jump to 2529.68 |
|
|
that five hour |
4.959 |
Jump to 2532.16 |
|
|
for for two hours for three hours versus |
5.521 |
Jump to 2537.119 |
|
|
only having 10 15 minutes of teaching i |
4.72 |
Jump to 2539.92 |
|
|
even with intensive aba therapy 30 hours |
5.76 |
Jump to 2560.88 |
|
|
40 hours a week there's |
4.48 |
Jump to 2564.24 |
|
|
teaching for one-on-one teaching okay |
4.639 |
Jump to 2579.2 |
|
|
one-step curtain so the audience may |
3.28 |
Jump to 2583.839 |
|
|
amount of psilocybin say 1.5 milligrams |
7.601 |
Jump to 2617.839 |
|
|
on a repetitive basis not just one bolus |
6.32 |
Jump to 2631.68 |
|
|
receptor they're called the 5 hd 1a |
7.44 |
Jump to 2657.28 |
|
|
receptor 5 ht1c receptor and those are |
5.839 |
Jump to 2660.24 |
|
|
10 hours of aba therapy a week to |
5.2 |
Jump to 2733.68 |
|
|
upwards of 30 or 40 hours a week |
4.641 |
Jump to 2736.319 |
|
|
hour of aba can again range from 40 or |
5.2 |
Jump to 2740.96 |
|
|
45 dollars up to sixty or seventy |
3.28 |
Jump to 2743.839 |
|
|
of about twenty thousand dollars so |
4.16 |
Jump to 2776.64 |
MONEY
about twenty thousand dollars
|
|
twenty thousand dollars per year that's |
3.28 |
Jump to 2778.88 |
MONEY
twenty thousand dollars
|
|
two or three months |
3.04 |
Jump to 2796.48 |
|
|
between 40 to 60 if not more thousands |
4.719 |
Jump to 2810.4 |
CARDINAL
between 40 to 60
|
|
providing twenty thousand dollars okay |
4.081 |
Jump to 2817.839 |
MONEY
twenty thousand dollars
|
|
war off the charts i mean 50 grand |
6.96 |
Jump to 2826.8 |
|
|
states is about 1200 to 1400 |
5.601 |
Jump to 2848.079 |
CARDINAL
about 1200 to 1400
|
|
i think it's 12 |
5.2 |
Jump to 2865.04 |
|
|
spending 50 grand |
4.24 |
Jump to 2894.16 |
|
|
know 40 50 you know 40 grand |
3.84 |
Jump to 2898.4 |
|
|
30-day study |
5.76 |
Jump to 2914.64 |
|
|
in 15 to 20 fragile x children |
4.96 |
Jump to 2916.48 |
|
|
approves drug that adds 30 days to a |
5.76 |
Jump to 2929.04 |
|
|
person who they love for another 30 days |
5.92 |
Jump to 2937.52 |
|
|
in an autistic child that's three four |
6.64 |
Jump to 2949.52 |
|
|
five years of age that has another 40 50 |
5.36 |
Jump to 2952.8 |
|
|
by only 10 or 15 percent |
5.84 |
Jump to 2958.16 |
|
|
we're first beginning we're we're |
3.68 |
Jump to 2992.8 |
|
|
results from the phase two a step so |
4.801 |
Jump to 3001.119 |
|
|
this project i said to them first i do a |
6.4 |
Jump to 3066.8 |
|
|
we have to agree that the first thing |
4.24 |
Jump to 3100.96 |
|
|
of schedule one psilocybin in the united |
5.039 |
Jump to 3130.8 |
|
|
because it's a schedule one i wish we |
4.24 |
Jump to 3141.28 |
|
|
30 days we submit our application |
5.119 |
Jump to 3166.72 |
|
|
we're different than every other one in |
3.921 |
Jump to 3188.559 |
|
|
we're using pure almost 100 pure |
5.04 |
Jump to 3196.88 |
|
|
i say weeks we're talking you know six |
4.24 |
Jump to 3221.119 |
|
|
roughly i'm exaggerating it's six to |
5.039 |
Jump to 3223.28 |
|
|
eight right ballpark yeah six to eight |
5.521 |
Jump to 3225.359 |
|
|
i'm you know weeks multiple so six to |
5.04 |
Jump to 3228.319 |
|
|
eight weeks away um |
6.08 |
Jump to 3230.88 |
|
|
one of the largest cross in canada kgk |
5.04 |
Jump to 3242.88 |
|
|
it a 72 page dossier |
7.039 |
Jump to 3251.04 |
|
|
72 pages that's the whole clinical |
5.601 |
Jump to 3255.119 |
|
|
is that when you submit they have 30 to |
4.88 |
Jump to 3294.0 |
|
|
45 days to respond |
4.4 |
Jump to 3296.24 |
|
|
and the study will go for you said 30 |
5.2 |
Jump to 3305.359 |
|
|
probably six |
4.88 |
Jump to 3314.0 |
|
|
we even have three children in norway |
4.72 |
Jump to 3320.72 |
|
|
the pre-clinical results in five |
6.161 |
Jump to 3427.119 |
|
|
animal studies no one's seen this yet we |
5.52 |
Jump to 3430.319 |
|
|
want to file patents on it first |
4.319 |
Jump to 3433.28 |
|
|
a second i i believe that nova mentis is |
3.599 |
Jump to 3466.48 |
|
|
having two projects underway |
5.76 |
Jump to 3470.079 |
|
|
correct marvin yes absolutely 300 |
5.28 |
Jump to 3479.76 |
|
|
approval that has been launched in two |
6.16 |
Jump to 3495.04 |
|
|
weeks we already have enrolled 60 |
4.64 |
Jump to 3498.0 |
|
|
going into the families we're 60 in less |
6.88 |
Jump to 3520.88 |
|
|
than in less than three weeks |
3.84 |
Jump to 3523.92 |
DATE
less than three weeks
|
|
able to feel that one a little bit |
2.56 |
Jump to 3545.2 |
|
|
occurrence of frequency in bales one in |
4.56 |
Jump to 3605.2 |
|
|
four thousand one and seven thousand so |
4.159 |
Jump to 3607.68 |
DATE
four thousand one and
|
|
so there's really this there's two |
3.279 |
Jump to 3635.04 |
|
|
that i'm sorry i got i got these two |
4.96 |
Jump to 3640.0 |
|
|
observational study in 300 patients we |
5.441 |
Jump to 3717.839 |
|
|
this was the first step |
4.08 |
Jump to 3756.88 |
|
|
start the study develop your 1.5 |
4.641 |
Jump to 3764.319 |
|
|
schedule one drug |
3.44 |
Jump to 3768.96 |
|
|
to have and we'll have the 1.5 milligram |
3.6 |
Jump to 3789.28 |
|
|
well the first thing we have to do is |
4.08 |
Jump to 3811.039 |
|
|
and i've done two of those myself |
3.76 |
Jump to 3880.48 |
|
|
we have 20 patients enrolled what if i |
4.641 |
Jump to 3940.319 |
|
|
look at 10 patients i can look at the |
4.719 |
Jump to 3942.88 |
|
|
you want me to continue for 20 or can we |
4.0 |
Jump to 3958.72 |
|
|
look at 10 |
4.56 |
Jump to 3961.44 |
|
|
commit we're committing to 20 patients |
6.159 |
Jump to 3985.2 |
|
|
okay now you have about a 20 drop out in |
5.04 |
Jump to 3988.16 |
|
|
20 |
4.639 |
Jump to 3996.16 |
|
|
of 20 is four so now you have 16 |
4.0 |
Jump to 3997.839 |
|
|
those 20 patients |
5.04 |
Jump to 4006.96 |
|
|
which i've done called the phase three |
5.68 |
Jump to 4025.359 |
|
|
this is an open clinical study phase two |
6.32 |
Jump to 4027.68 |
|
|
focused on one thing i'm sorry you know |
4.081 |
Jump to 4051.599 |
|
|
we should pay 200 |
3.44 |
Jump to 4144.319 |
|
|
which one's at phase one phase two phase |
5.12 |
Jump to 4156.4 |
|
|
three and see which ones went this forty |
4.641 |
Jump to 4158.799 |
|
|
to eighty dollars a share then the next |
3.759 |
Jump to 4161.52 |
|
|
day they're at five dollars because the |
5.12 |
Jump to 4163.44 |
|
|
phase three study didn't work right |
4.88 |
Jump to 4165.279 |
|
|
the phase two way study |
4.161 |
Jump to 4179.279 |
|
|
no 100 i mean that that's really i mean |
4.479 |
Jump to 4188.88 |
|
|
phase two then when you get the data |
3.681 |
Jump to 4198.719 |
|
|
get to face three i mean by the time you |
3.84 |
Jump to 4204.8 |
|
|
go from phase three to commercialization |
4.08 |
Jump to 4206.96 |
|
|
who has the 300 page autism |
4.56 |
Jump to 4269.04 |
|
|
this company has 52 genes |
5.84 |
Jump to 4281.76 |
|
|
and field that one so zach these are |
5.681 |
Jump to 4368.239 |
|
|
potentially one of the greatest |
4.96 |
Jump to 4422.56 |
|
|
million dollar question |
3.759 |
Jump to 4429.44 |
|
|
symptoms 24 hours a day |
6.72 |
Jump to 4495.12 |
|
|
all this data are you going to take 20 |
4.881 |
Jump to 4606.159 |
|
|
with 100 points on each sheet and how |
4.8 |
Jump to 4611.04 |
|
|
we'll follow up in uh you know six to |
3.279 |
Jump to 4655.44 |
|
|
eight weeks |
2.081 |
Jump to 4657.679 |
|
|