| justice kovitt emerged in march of 2020 | 5.36 | Jump to 1.439 |  |  | 
              
                
                  | expert for more than 35 years he was | 5.2 | Jump to 8.96 |  |  | 
              
                
                  | health in 1984. in this role he has | 6.48 | Jump to 18.16 |  |  | 
              
                
                  | advised five presidents he led the | 5.2 | Jump to 21.52 |  |  | 
              
                
                  | and as you can see from this first slide | 5.681 | Jump to 72.159 |  |  | 
              
                
                  | the five six elements that i'm going to | 4.32 | Jump to 86.96 |  |  | 
              
                
                  | the first | 4.56 | Jump to 91.28 |  |  | 
              
                
                  | next yeah the first is epidemiology next | 4.64 | Jump to 92.4 |  |  | 
              
                
                  | of 2020 to now this has emerged | 6.561 | Jump to 103.759 |  |  | 
              
                
                  | over 100 years with about 275 million | 6.48 | Jump to 112.56 | 
                      
                        
                      
                        CARDINAL
                      
                      
                        about 275 million
                      
                     |  | 
              
                
                  | cases and over 5 million deaths globally | 4.24 | Jump to 116.32 |  |  | 
              
                
                  | that we are one of the handful of | 5.121 | Jump to 123.439 |  |  | 
              
                
                  | 50 million cases and just last week | 7.121 | Jump to 130.399 |  |  | 
              
                
                  | of over 800 000 deaths next slide | 7.12 | Jump to 137.52 |  |  | 
              
                
                  | and if one goes to the far right hand | 4.801 | Jump to 154.879 |  |  | 
              
                
                  | of 2021 | 4.32 | Jump to 162.08 |  |  | 
              
                
                  | an rna virus that has four structural | 5.761 | Jump to 197.519 |  |  | 
              
                
                  | transmissibility now because of our two | 4.72 | Jump to 230.0 |  |  | 
              
                
                  | of this particular virus one | 5.92 | Jump to 296.96 |  |  | 
              
                
                  | at least a third and maybe 40 percent | 6.16 | Jump to 299.36 | 
                      
                        
                      
                        CARDINAL
                      
                      
                        at least a third
                      
                     |  | 
              
                
                  | killing eight hundred thousand people in | 4.561 | Jump to 313.759 | 
                      
                        
                      
                        CARDINAL
                      
                      
                        eight hundred thousand
                      
                     |  | 
              
                
                  | is that about sixty percent | 5.92 | Jump to 320.32 | 
                      
                        
                      
                        PERCENT
                      
                      
                        about sixty percent
                      
                     |  | 
              
                
                  | one unique aspect | 6.081 | Jump to 355.199 |  |  | 
              
                
                  | 81 percent are mild to moderate and | 5.12 | Jump to 376.96 |  |  | 
              
                
                  | about 15 to 20 percent | 4.8 | Jump to 379.44 |  |  | 
              
                
                  | case fatality rate of anywhere from two | 5.679 | Jump to 384.24 |  |  | 
              
                
                  | to three percent up to about 20 percent | 4.799 | Jump to 386.96 |  |  | 
              
                
                  | one's thoughts next slide | 5.68 | Jump to 502.4 |  |  | 
              
                
                  | now we'll just spend a moment or two on | 4.72 | Jump to 525.6 |  |  | 
              
                
                  | into two components | 5.28 | Jump to 530.32 |  |  | 
              
                
                  | one is to treat the virus itself | 5.6 | Jump to 532.56 |  |  | 
              
                
                  | on the saws kobe 2 replication cycle and | 4.72 | Jump to 575.04 |  |  | 
              
                
                  | one can design inhibitors for example of | 5.521 | Jump to 605.279 |  |  | 
              
                
                  | the virus one in particular | 4.72 | Jump to 628.48 |  |  | 
              
                
                  | remarkable almost 90 percent reduction | 6.4 | Jump to 640.8 | 
                      
                        
                      
                        PERCENT
                      
                      
                        almost 90 percent
                      
                     |  | 
              
                
                  | if there is one success story | 5.841 | Jump to 653.519 |  |  | 
              
                
                  | to deem the development of covet 19 | 3.92 | Jump to 672.56 |  |  | 
              
                
                  | three separate platforms you're all | 4.16 | Jump to 689.44 |  |  | 
              
                
                  | vaccines in the united states one | 5.92 | Jump to 702.88 |  |  | 
              
                
                  | which up until recently had more than 95 | 6.0 | Jump to 759.12 |  |  | 
              
                
                  | 175 countries | 3.8 | Jump to 773.0 |  |  | 
              
                
                  | two times more transmissible than the | 4.239 | Jump to 788.16 |  |  | 
              
                
                  | first isolated in southern africa it is | 6.56 | Jump to 817.519 |  |  | 
              
                
                  | these two rather complicated looking | 4.72 | Jump to 840.88 |  |  | 
              
                
                  | so if you look at all of three these | 3.68 | Jump to 888.399 |  |  | 
              
                
                  | three questions | 5.2 | Jump to 890.48 |  |  | 
              
                
                  | this is the rolling seven-day average | 5.12 | Jump to 900.959 |  |  | 
              
                
                  | over their two doses of for example an | 6.4 | Jump to 1000.48 |  |  | 
              
                
                  | 21 days after the second dose | 5.519 | Jump to 1014.32 |  |  | 
              
                
                  | one month after the third booster shot | 5.199 | Jump to 1041.6 |  |  | 
              
                
                  | square of triangles where it says one | 3.361 | Jump to 1071.039 |  |  | 
              
                
                  | and five months after a two dose vaccine | 6.8 | Jump to 1074.4 |  |  | 
              
                
                  | on the left on the one month five months | 7.04 | Jump to 1088.32 | 
                      
                        
                      
                        DATE
                      
                      
                        the one month five months
                      
                     |  | 
              
                
                  | when you look at two weeks | 4.96 | Jump to 1100.0 |  |  | 
              
                
                  | post a dose 2 | 5.04 | Jump to 1102.48 |  |  | 
              
                
                  | two weeks after the boost it goes right | 3.841 | Jump to 1111.919 |  |  | 
              
                
                  | diminishes to about 33 percent | 6.08 | Jump to 1132.32 |  |  | 
              
                
                  | it's still around 70 percent but that's | 4.56 | Jump to 1138.4 | 
                      
                        
                      
                        PERCENT
                      
                      
                        around 70 percent
                      
                     |  | 
              
                
                  | from the 93 percent | 5.28 | Jump to 1142.96 |  |  | 
              
                
                  | who have gotten the two dose mrna | 5.92 | Jump to 1168.48 |  |  | 
              
                
                  | it goes way down after the second boost | 5.44 | Jump to 1201.28 |  |  | 
              
                
                  | compromises the effects of a two-dose | 5.76 | Jump to 1221.44 |  |  | 
              
                
                  | for as we enter 2022 and beyond | 6.24 | Jump to 1285.12 |  |  | 
              
                
                  | eradicate this we've only eradicated one | 4.56 | Jump to 1298.72 |  |  | 
              
                
                  | a level of infection that isn't zero | 6.481 | Jump to 1333.039 |  |  | 
              
                
                  | but if i were to pick out one thing that | 5.201 | Jump to 1437.039 |  |  | 
              
                
                  | and you have 50 million people in the | 3.28 | Jump to 1450.72 |  |  | 
              
                
                  | is killed already over 800 000 americans | 7.68 | Jump to 1553.52 |  |  | 
              
                
                  | said that 60 | 3.279 | Jump to 1639.12 |  |  | 
              
                
                  | everybody's having a good time and 50 of | 5.52 | Jump to 1665.84 |  |  | 
              
                
                  | there was one or more person | 4.959 | Jump to 1673.6 |  |  | 
              
                
                  | the other thing one can do | 4.161 | Jump to 1751.279 |  |  | 
              
                
                  | but vaccinated and boosted people one of | 4.4 | Jump to 1765.2 |  |  | 
              
                
                  | right the government has now put out 10 | 6.319 | Jump to 1826.08 |  |  | 
              
                
                  | 000 centers that are giving away free | 4.16 | Jump to 1829.2 |  |  | 
              
                
                  | have invested 3 billion dollars to make | 5.439 | Jump to 1833.36 |  |  | 
              
                
                  | 200 million | 6.081 | Jump to 1836.799 |  |  | 
              
                
                  | to 500 million tests available per month | 5.521 | Jump to 1838.799 |  |  | 
              
                
                  | ten thousand ten thousand so | 5.36 | Jump to 1864.48 | 
                      
                        
                      
                        DATE
                      
                      
                        ten thousand ten thousand
                      
                     |  | 
              
                
                  | uh that post where those ten thousand | 5.199 | Jump to 1869.84 |  |  | 
              
                
                  | kids and kids that are aged um two | 5.201 | Jump to 1945.279 |  |  | 
              
                
                  | through five years old the most recent | 4.321 | Jump to 1948.559 |  |  | 
              
                
                  | vaccine for that two to five year old | 4.079 | Jump to 1959.84 | 
                      
                        
                      
                        DATE
                      
                      
                        two to five year old
                      
                     |  | 
              
                
                  | fisa it was 30 micrograms for the adults | 6.079 | Jump to 1980.08 |  |  | 
              
                
                  | then when it went down to 12 | 6.0 | Jump to 1983.84 |  |  | 
              
                
                  | it was i mean 5 to 11 it was | 6.081 | Jump to 1986.159 |  |  | 
              
                
                  | one-third of that which was | 4.719 | Jump to 1989.84 |  |  | 
              
                
                  | uh three excuse me uh | 5.12 | Jump to 1992.24 |  |  | 
              
                
                  | yeah one-third of that which was ten and | 5.281 | Jump to 1994.559 |  |  | 
              
                
                  | then it went down to three | 3.6 | Jump to 1997.36 |  |  | 
              
                
                  | six months to 24 months it looked good | 4.56 | Jump to 2004.08 | 
                      
                        
                      
                        DATE
                      
                      
                        six months to 24 months
                      
                     |  | 
              
                
                  | but that lower dose of three micrograms | 6.879 | Jump to 2008.64 |  |  | 
              
                
                  | two years old to four plus | 5.36 | Jump to 2017.12 |  |  | 
              
                
                  | that this is really a three dose vaccine | 6.0 | Jump to 2026.88 |  |  | 
              
                
                  | three doses you're going to get an | 3.919 | Jump to 2032.88 |  |  | 
              
                
                  | until the end of the first quarter of | 7.121 | Jump to 2055.119 |  |  | 
              
                
                  | 2022 so instead of getting vaccines | 6.799 | Jump to 2058.32 |  |  | 
              
                
                  | for children from six months to four | 4.96 | Jump to 2062.24 |  |  | 
              
                
                  | in the beginning of 2022 it likely will | 8.24 | Jump to 2067.2 | 
                      
                        
                      
                        DATE
                      
                      
                        the beginning of 2022
                      
                     |  | 
              
                
                  | not be for a few months into 2022 wow | 7.921 | Jump to 2069.839 |  |  | 
              
                
                  | for 15 vaccine preventable diseases when | 5.919 | Jump to 2086.24 |  |  | 
              
                
                  | against saw's kobe 2 to prevent covid | 4.079 | Jump to 2145.52 |  |  | 
              
                
                  | one of the main ways that it's spread | 7.52 | Jump to 2172.64 |  |  | 
              
                
                  | apropos what i told you about the 60 | 4.0 | Jump to 2226.079 |  |  | 
              
                
                  | uh one is that | 4.16 | Jump to 2530.0 |  |  | 
              
                
                  | well as i showed on the last two slides | 4.879 | Jump to 2586.48 |  |  | 
              
                
                  | it is impossible that the third shot | 5.28 | Jump to 2645.76 |  |  | 
              
                
                  | and maybe an additional one | 3.84 | Jump to 2651.04 | 
                      
                        
                      
                        CARDINAL
                      
                      
                        an additional one
                      
                     |  | 
              
                
                  | two shots | 3.68 | Jump to 2656.8 |  |  | 
              
                
                  | the immunity goes down after six months | 3.52 | Jump to 2658.0 |  |  | 
              
                
                  | that third shot booster is going to make | 2.879 | Jump to 2665.2 |  |  | 
              
                
                  | surge 60 surging units paying attention | 6.319 | Jump to 2726.8 |  |  | 
              
                
                  | vaccine that's one of the good things | 3.68 | Jump to 2846.48 |  |  | 
              
                
                  | people who have had at least one jnj | 5.921 | Jump to 2863.119 |  |  | 
              
                
                  | shot be considered for a fourth shot of | 5.399 | Jump to 2865.44 |  |  | 
              
                
                  | that's one of the things about our | 2.32 | Jump to 2926.96 |  |  | 
              
                
                  | 2022 | 3.36 | Jump to 2987.44 |  |  | 
              
                
                  | minister of one of my favorite places | 5.92 | Jump to 2990.8 |  |  | 
              
                
                  | aruba on january 10th and a headliner | 6.24 | Jump to 2993.04 |  |  | 
              
                
                  | discussion on january 13th | 5.52 | Jump to 3005.92 |  |  | 
              
                
                  | well answered the first question you | 4.0 | Jump to 3081.28 |  |  | 
              
                
                  | christmas because my children my three | 4.241 | Jump to 3112.559 |  |  | 
              
                
                  | last year for the first time since their | 3.12 | Jump to 3119.04 |  |  | 
              
                
                  | one final holiday question | 5.68 | Jump to 3177.76 |  |  |